Differential Reactivity of Microglia in Two Mouse Models of Multiple Sclerosis

i Acknowledgements I want to thank my advisor, Dr. Jeff Dupree, for providing me with knowledge and advice over the past two years, and for helping me learn what it means to be a researcher. He always urged me to learn more and move forward with a clear hypothesis in mind. His guidance was instrumental in completing my project and I cannot thank him enough for everything he has done for me. I would like to thank my other lab members for all their assistance and encouragement. I especially want to thank Kareem Clark and Savannah Benusa for providing me with their expertise and teaching me, and for their encouragement when obstacles arose. Their guidance was invaluable and I could not have completed this project without their help. I want to thank Nick George, my fellow master's student, for providing support as we persevered through our research together. I also want to thank Brooke Sword, our laboratory technician, for helping me with my mice and our undergraduate students for their assistance in various aspects of this project.